COVID-2019: update on epidemiology, disease spread and management.
Identifieur interne : 000889 ( Main/Exploration ); précédent : 000888; suivant : 000890COVID-2019: update on epidemiology, disease spread and management.
Auteurs : Kamal Kant Sahu [Oman] ; Ajay Kumar Mishra [Oman] ; Amos Lal [Oman]Source :
- Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace [ 1122-0643 ] ; 2020.
Descripteurs français
- KwdFr :
- AMP (analogues et dérivés), AMP (usage thérapeutique), Alanine (analogues et dérivés), Alanine (usage thérapeutique), Antiviraux (usage thérapeutique), Essais cliniques comme sujet, Humains, Infections à coronavirus (), Infections à coronavirus (diagnostic), Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (épidémiologie), Nombre de reproduction de base, Pandémies (), Peptidyl-Dipeptidase A (métabolisme), Pneumopathie virale (), Pneumopathie virale (diagnostic), Pneumopathie virale (épidémiologie), Quarantaine, Récepteurs viraux (métabolisme), Techniques de laboratoire clinique.
- MESH :
- analogues et dérivés : AMP, Alanine.
- diagnostic : Infections à coronavirus, Pneumopathie virale.
- métabolisme : Peptidyl-Dipeptidase A, Récepteurs viraux.
- traitement médicamenteux : Infections à coronavirus.
- usage thérapeutique : AMP, Alanine, Antiviraux.
- épidémiologie : Infections à coronavirus, Pneumopathie virale.
- Essais cliniques comme sujet, Humains, Infections à coronavirus, Nombre de reproduction de base, Pandémies, Pneumopathie virale, Quarantaine, Techniques de laboratoire clinique.
English descriptors
- KwdEn :
- Adenosine Monophosphate (analogs & derivatives), Adenosine Monophosphate (therapeutic use), Alanine (analogs & derivatives), Alanine (therapeutic use), Antiviral Agents (therapeutic use), Basic Reproduction Number, Betacoronavirus, Clinical Laboratory Techniques, Clinical Trials as Topic, Coronavirus Infections (diagnosis), Coronavirus Infections (drug therapy), Coronavirus Infections (epidemiology), Coronavirus Infections (prevention & control), Coronavirus Infections (therapy), Humans, Pandemics (prevention & control), Peptidyl-Dipeptidase A (metabolism), Pneumonia, Viral (diagnosis), Pneumonia, Viral (epidemiology), Pneumonia, Viral (prevention & control), Pneumonia, Viral (therapy), Quarantine, Receptors, Virus (metabolism).
- MESH :
- chemical , analogs & derivatives : Adenosine Monophosphate, Alanine.
- chemical , metabolism : Peptidyl-Dipeptidase A, Receptors, Virus.
- chemical , therapeutic use : Adenosine Monophosphate, Alanine, Antiviral Agents.
- diagnosis : Coronavirus Infections, Pneumonia, Viral.
- drug therapy : Coronavirus Infections.
- epidemiology : Coronavirus Infections, Pneumonia, Viral.
- prevention & control : Coronavirus Infections, Pandemics, Pneumonia, Viral.
- therapy : Coronavirus Infections, Pneumonia, Viral.
- Basic Reproduction Number, Betacoronavirus, Clinical Laboratory Techniques, Clinical Trials as Topic, Humans, Quarantine.
Abstract
With each passing day, more cases of Coronavirus disease (COVID-2019) are being detected and unfortunately the fear of novel corona virus 2019 (2019-nCoV) becoming a pandemic disease has come true. Constant efforts at individual, national, and international level are being made in order to understand the genomics, hosts, modes of transmission and epidemiological link of nCoV-2019. As of now, whole genome sequence of the newly discovered coronavirus has already been decoded. Genomic characterization nCoV-2019 have shown close homology with bat-derived severe acute respiratory syndrome (SARS)-like coronaviruses, bat-SL-CoVZC45 and bat-SL-CoVZXC21. Structural analysis of the receptor binding site has confirmed that 2019-nCoV binds with the same ACE 2 receptor protein as human SARS virus. Compared to the previous coronavirus outbreaks, the overall mortality rate is relatively low for COVID-2019 (2-3%). Suspected cases must be quarantined till their test comes positive or they clear infection. At present, treatment of COVID-2019 is mostly based on the knowledge gained from the SARS and MERS outbreaks. Remdesivir, originally develop as a treatment for Ebola virus disease and Marburg virus infections, is being studied for it effectiveness against 2019-nCoV infection. Many other antiviral agents and vaccines are being tested but most of them are in phase I or II and hence unlikely to be of any benefit immediately with regards to current outbreak. Hence, the standard infection control techniques and preventive steps for healthy individuals and supportive care for the confirmed cases is the best available strategy to deal with current viral outbreak. .
DOI: 10.4081/monaldi.2020.1292
PubMed: 32297723
Affiliations:
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Le document en format XML
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use)</term><term>Basic Reproduction Number</term><term>Betacoronavirus</term><term>Clinical Laboratory Techniques</term><term>Clinical Trials as Topic</term><term>Coronavirus Infections (diagnosis)</term><term>Coronavirus Infections (drug therapy)</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (prevention & control)</term><term>Coronavirus Infections (therapy)</term><term>Humans</term><term>Pandemics (prevention & control)</term><term>Peptidyl-Dipeptidase A (metabolism)</term><term>Pneumonia, Viral (diagnosis)</term><term>Pneumonia, Viral (epidemiology)</term><term>Pneumonia, Viral (prevention & control)</term><term>Pneumonia, Viral (therapy)</term><term>Quarantine</term><term>Receptors, Virus (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>AMP (analogues et dérivés)</term><term>AMP (usage thérapeutique)</term><term>Alanine (analogues et dérivés)</term><term>Alanine (usage thérapeutique)</term><term>Antiviraux (usage thérapeutique)</term><term>Essais cliniques comme sujet</term><term>Humains</term><term>Infections à coronavirus ()</term><term>Infections à coronavirus (diagnostic)</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Infections à coronavirus (épidémiologie)</term><term>Nombre de reproduction de base</term><term>Pandémies ()</term><term>Peptidyl-Dipeptidase A (métabolisme)</term><term>Pneumopathie virale ()</term><term>Pneumopathie virale (diagnostic)</term><term>Pneumopathie virale (épidémiologie)</term><term>Quarantaine</term><term>Récepteurs viraux (métabolisme)</term><term>Techniques de laboratoire clinique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Adenosine Monophosphate</term><term>Alanine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Peptidyl-Dipeptidase A</term><term>Receptors, Virus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Adenosine Monophosphate</term><term>Alanine</term><term>Antiviral Agents</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>AMP</term><term>Alanine</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Peptidyl-Dipeptidase A</term><term>Récepteurs viraux</term></keywords><keywords scheme="MESH" qualifier="prevention & control" 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Constant efforts at individual, national, and international level are being made in order to understand the genomics, hosts, modes of transmission and epidemiological link of nCoV-2019. As of now, whole genome sequence of the newly discovered coronavirus has already been decoded. Genomic characterization nCoV-2019 have shown close homology with bat-derived severe acute respiratory syndrome (SARS)-like coronaviruses, bat-SL-CoVZC45 and bat-SL-CoVZXC21. Structural analysis of the receptor binding site has confirmed that 2019-nCoV binds with the same ACE 2 receptor protein as human SARS virus. Compared to the previous coronavirus outbreaks, the overall mortality rate is relatively low for COVID-2019 (2-3%). Suspected cases must be quarantined till their test comes positive or they clear infection. At present, treatment of COVID-2019 is mostly based on the knowledge gained from the SARS and MERS outbreaks. Remdesivir, originally develop as a treatment for Ebola virus disease and Marburg virus infections, is being studied for it effectiveness against 2019-nCoV infection. Many other antiviral agents and vaccines are being tested but most of them are in phase I or II and hence unlikely to be of any benefit immediately with regards to current outbreak. Hence, the standard infection control techniques and preventive steps for healthy individuals and supportive care for the confirmed cases is the best available strategy to deal with current viral outbreak. .</div></front></TEI><affiliations><list><country><li>Oman</li></country></list><tree><country name="Oman"><noRegion><name sortKey="Sahu, Kamal Kant" sort="Sahu, Kamal Kant" uniqKey="Sahu K" first="Kamal Kant" last="Sahu">Kamal Kant Sahu</name></noRegion><name sortKey="Lal, Amos" sort="Lal, Amos" uniqKey="Lal A" first="Amos" last="Lal">Amos Lal</name><name sortKey="Mishra, Ajay Kumar" sort="Mishra, Ajay Kumar" uniqKey="Mishra A" first="Ajay Kumar" last="Mishra">Ajay Kumar Mishra</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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